Shimek is the Anglicized spelling of the Slavic surname Šimek. The name comes from a hypocorism of the name Šimon. Simek is a surname that may be either Anglicized spelling of Šimek, or directly a Slavic hypocorism of the name Simon. Notable people with the surname include:

Shimek Bohumil Shimek (1861–1937), American naturalist and conservationist Liz Moeggenberg née Shimek (born 1984), American basketball player

Simek Artie Simek (1916–1975), American calligrapher best known as a letterer for Marvel Comics Frank Simek (born 1984), American association football player Péter Simek (born 1980), Hungarian association football player Rudolf Simek (born 1954), Austrian philologian and historian

See also Schimek, Germanized version of the name 14098 Šimek, an asteroid Shimek State Forest, Iowa, U.S.