Gastón de la Cerda, 3rd Duke of Medinaceli, Grandee of Spain, (in full, ), (c. 1507 – 1552) was a Spanish nobleman.
He was the second son of Don Juan de la Cerda, 2nd Duke of Medinaceli, by his first wife Mencía Manuel de Portugal. As a young man he became a monk in the Order of St. Jerome. In 1536, after the death of his elder brother Luis without issue, he became the heir to the family titles, so he sought a Papal dispensation in order to marry and fulfill his family obligations. On 4 March 1540 he married María Sarmiento de la Cerda, a marriage that was eventually annulled on 30 August 1544, having produced no issue.
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