Ursúa, Ursua, Urzúa or Urzua is a Basque surname. Notable people with the surname include:
Adolfo Holley Urzua (1833–1914), Chilean general Antonio María de Bucareli y Ursúa (1717–1779), Spanish military officer, governor of Cuba, viceroy of New Spain Carlos Manuel Urzúa Macías (1955–2024), Mexican politician and academic Diego Urzúa (born 1997), Chilean professional footballer Domingo Vega Urzúa, also known as Americo, Chilean musician Francisco de Paula Bucareli y Ursua (1708–1780), his brother, Governor of the Rio de la Plata, viceroy of Navarre José Domingo Jaramillo Urzúa (1851–1916), Chilean farmer and politician Luis Urzúa, Chilean miner, and shift foreman and leader of the trapped miners during the 2010 Copiapó mining accident Marcelo Urzúa (born 1962), Chilean footballer María Guadalupe Urzúa Flores (1912–2004), Mexican politician and activist María José Urzúa, Chilean actress Martín de Ursúa y Arizmendi, count of Lizárraga (1653–1715), Spanish conquistador during the final conquest of the Maya in 1697 Pedro de Ursúa (1526–1561), Spanish conquistador in the 16th century Pedro Verdugo de Albornoz Ursúa (1657–1720), Spanish noble and academician Ricardo Urzúa Rivera (born 1966), Mexican politician from the Institutional Revolutionary Party (PRI)