Irion is a surname. Notable people with the surname include:
Alfred Briggs Irion (1833–1903), U.S. Representative from Louisiana Johnny Irion (born 1969) and Sarah Lee Guthrie (born 1979), United States musical duo Robert Anderson Irion (1804–1861), physician, surveyor and Secretary of State of Texas Naomi Irion (2003–2022), American murder victim
See also Irion County, Texas, county located in the U.S. state of Texas