Stikine, meaning "great river" in the Tlingit language, may refer to:

Geography and locations Stikine River, a major river in British Columbia and Alaska Stikine Strait, a marine waterway in Alaska offshore from the mouth of the Stikine River, near Wrangell, Alaska Fort Stikine, a trading post and fortification of the Hudson's Bay Company at what is now Wrangell, Alaska Stikine Country, aka the Stikine District, a geographic region of the Canadian province of British Columbia, roughly equivalent to the Stikine Mining Division aka Stikine Mining District of the British Columbia Dept. of Mines Stikine Plateau, a large regional landform in northwestern British Columbia, inclusive of the Stikine and Taku River basins Stikine Ranges, a major subgrouping of the Cassiar Mountains of northern British Columbia Stikine, British Columbia, aka Boundary, an unincorporated locality and former customs post on the lower Stikine River Stikine River Provincial Park, a provincial park protecting the Grand Canyon of the Stikine River Stikine Hot Springs, a hot spring on the lower Stikine River protected by Choquette Hot Springs Provincial Park Stikine Volcanic Belt, a subgrouping of volcanoes within the Northern Cordilleran Volcanic Province in British Columbia Stikine Icecap, a large icefield in the Boundary Ranges of the Coast Mountains, spanning the British Columbia-Alaska border Stikine-LeConte Wilderness, a park in the Alaska Panhandle Tongass/Stikine National Forest, aka the Tongass National Forest, a US national forest in Alaska Klondike Gold Rush#Takou, Stikine and Edmonton routes

Political units Stikine Territory, formally the Stickeen Territories, a former British overseas territory established in 1861, absorbed into the Colony of British Columbia in 1863 Stikine Region, an administrative region of the Canadian province of British Columbia Regional District of Kitimat-Stikine, a regional district in northwestern British Columbia Stikine (provincial electoral district), a provincial electoral district in northwestern British Columbia

People Stikine people (Shtaxʼhéen Ḵwáan), a ḵwáan or regional group of the Tlingit