Robert E. Lee Hotel or Hotel Robert E. Lee or variations may refer to:
Robert E. Lee Hotel (San Diego, California), listed on the National Register of Historic Places in San Diego County, California Robert E. Lee Hotel (St. Louis, Missouri), listed on the National Register of Historic Places in St. Louis County, Missouri Hotel Robert E. Lee (Winston-Salem, North Carolina), once the tallest building in Winston-Salem Robert E. Lee Hotel (San Antonio, Texas), listed on the National Register of Historic Places in Bexar County, Texas