Hyriidae is a taxonomic family of pearly freshwater mussels, aquatic bivalve molluscs in the order Unionida. This family is native to South America, Australia, New Zealand and New Guinea. Like all members of that order, they go through a larval stage that is parasitic on fish (see glochidium).

The classification recognized by Banarescu (1995) uses three subfamilies. This family contains eighteen genera.

Subfamilies and genera Hyriinae Genera within the subfamily Hyriinae, from South America, include:

Paxyodon Castalina Chevronaias Tribe Castaliini Castalia Castaliella Callonaia Tribe Hyriini Prisodon Triplodon Tribe Rhipidodontini Diplodon

Cucumerunioninae Genera within the subfamily Cucumerunioninae, from Australasia, include: Echyridella Cucumerunio Hyridella Virgus

Velesunioninae Genera within the subfamily Velesunioninae, from Australasia, include: Alathyria Alathyria jacksoni, the river mussel (or black river mussel) occurs in South Australia. Haasodonta Lortiella Microdonta Velesunio Westralunio

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