William Wickham may refer to:
William Wickham (bishop) (1539–1595), English bishop William Wickham (civil servant) (1761–1840), British civil servant and politician; spymaster during the French Revolution William Wickham (cricketer) (1825–1845), English cricketer William Wickham (Conservative politician) (1831–1897), Member of Parliament for Petersfield, 1892–1897; grandson of William Wickham (1761–1840) William Wickham (New York politician) (1871–1959), American farmer, businessman, member of the New York State Assembly William Wickham (1782–1860), social reformer and campaigner for the Parliamentary Reform Act 1832 William H. Wickham (1832–1893), New York mayor
See also William of Wykeham (1320–1404), Bishop of Winchester and Lord Chancellor Williams Carter Wickham (1820–1888), American lawyer, judge, politician, and Confederate cavalry general