Isa Khan may refer to:
Isa Khan of Bengal, 16th-century Baro-Bhuiyan noble of Bengal Isa Khan Niazi, 16th century Afghan noble of the Sur Empire of northern India, in Sher Shah Suri's royal court Tomb of Isa Khan, his located in the UNESCO World Heritage Site of Humayun's Tomb complex in Delhi, India Isa Khan Sheykhavand, 17th century Safavid prince who occupied high offices under Shah Abbas I Prince Jesse of Kakheti or 'Isa Khan Gorji, Georgian noble, whose career flourished in the service of the Safavid dynasty of Iran Jesse of Kakheti or Isā Khān, Safavid-appointed ruler from the Bagrationi dynasty of Kakheti in eastern Georgia from 1614 to 1615 Isa Khan (Guantanamo detainee 23), United States held Afghani, in extrajudicial detention in Guantanamo Bay Isha Khan Choudhury (born 1971), Indian politician Ustad Isa, 16th-century architect of the Taj Mahal in Agra, India Isa Khan, Iran, a village in West Azerbaijan Province, Iran Eshaqvand-e Olya or Isa Khan-e Olya, a village in Kermanshah Province, Iran Eshaqvand-e Sofla or Isa Khan-e Sofla, a village in Kermanshah Province, Iran