Isakov () is a Slavic-language patronymic surname, a derivative from "Isaac". It may refer to the following people:
Dimitar Isakov (born 1924), Bulgarian football player Eduard Isakov (born 1973), Russian politician Evgeny Isakov (born 1984), Russian ice hockey player Gregory Alan Isakov (born 1979), South African-American singer-songwriter Ismail Isakov (born 1950), Kyrgyzstan politician and Lieutenant General in the Kyrgyz military Ivan Isakov (1894–1967), Soviet Armenian Admiral of the Fleet Mile Isakov (born 1950), Serbian politician and journalist Pyotr Isakov (1900–1957), Soviet football player and manager Victor Isakov (1947–2021), American mathematician Vladimir Isakov (disambiguation), multiple people Yuri Isakov (1912–1988), Soviet ornithologist and biogeographer Yury Isakov (1949–2013), Soviet pole vaulter
See also Isaacs Isaak