TGIF may refer to:
Arts and media TGIF (TV programming block), a former two-hour programming block on the American television network ABC "TGIF" (song), a song by GloRilla "Last Friday Night (T.G.I.F.)", a 2011 single by Katy Perry "T.G.I.F. (Thank God I'm Fresh)", a song by Kid Cudi from Man on the Moon: The End of Day "T.G.I.F.", a song by Lonestar from Let's Be Us Again "TGIF", a song by K.Flay from Inside Voices / Outside Voices "TGIF", a song by Le Tigre from Feminist Sweepstakes
Science and technology Tgif (program), an interactive 2-D drawing tool under X11 for Unix and the file format it uses, .tgif Tactical Ground Intercept Facility, a US military intelligence collection platform Transforming growth interacting factor TGIF1, a protein that in humans is encoded by the TGIF1 gene TGIF2, a protein that in humans is encoded by the TGIF2 gene
Other uses Thank God It's Friday (disambiguation) TGI Fridays, an American restaurant chain