Sodium butyrate is a compound with formula . It is the sodium salt of butyric acid. It is a white, water-soluble, crystalline solid having the odor of butyric acid.

Occurrence Sodium butyrate is a common source of butyrate which forms when butyric acid is dissolved near neutral pH. Butyrate is a common metabolite that is produced by hydrolysis of butyryl-CoA.

Medical research Butyrate affects histone deacetylase, which is tied to DNA processing. Sodium butyrate is under preliminary research for its potential to mitigate traveler's diarrhea.

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