Millspaugh is a surname. Notable people with the surname include:
Arthur Millspaugh (1883–1955), adviser at the U.S. State Department's Office of the Foreign Trade Charles Frederick Millspaugh (1854–1923), American botanist Frank Millspaugh (disambiguation): Frank C. Millspaugh (1872–1947), U.S. Representative from Missouri Frank Rosebrook Millspaugh (1848–1916), bishop of Kansas
See also Millspaugh, California, unincorporated community in Inyo County, California