Tuxen is a Danish and Norwegian surname. Notable people with the surname include:
Anne Vilde Tuxen (born 1998), Norwegian diver Erik Tuxen (1902–1957), Danish conductor Fanny Tuxen (1832–1906), Danish writer Helle Tuxen (born 2001), Norwegian diver Laurits Tuxen (1853–1927), Danish painter Nicoline Tuxen (1847–1931), Danish painter Saxil Tuxen (1885–1975), Australian town planner
See also Cape Tuxen