Sharpless is a surname. Notable people with the surname include:
Bevan Sharpless (1904–1950), American solar system astronomer Christopher Sharpless (1945–2025), American 1988 Winter Olympics bobsledder Isaac Sharpless (1848–1920), American educator Josh Sharpless (born 1988), American baseball player Karl Barry Sharpless (born 1941), American chemist and Nobel prize winner Mattie R. Sharpless (born 1943), American diplomat Nathan J. Sharpless (1823–1893), American politician from Pennsylvania Norman Sharpless (born 1966), American oncologist and director of the National Cancer Institute John Sharpless (born 1946), American retired history professor Stewart Sharpless (1926–2013), American galactic astronomer Sharpless catalog, a 20th-century astronomical catalog with 313 items Disappearance of Toni Sharpless (born 1979), American nurse who disappeared in 2009
Fictional characters A character in Madama Butterfly
See also Sharpless asymmetric dihydroxylation, a chemical reaction Sharpless epoxidation, a chemical reaction Sharpless oxyamination, a chemical reaction