SMX may refer to:

As an abbreviation: Honda S-MX, a minivan Singapore Mercantile Exchange S.M.X., director of Revelation at the 1999 New York Underground Film Festival SMX (operating system), a Unix-like simulator on SPARC, the "SunOS/Solaris MINIX" SMX Convention Center (company), an events venue management company in the Philippines SMX Convention Center Manila, Pasay, Philippines SmX RNA and SmY RNA, ribonucleic acids in nematode worms Spatial multiplexing, MIMO wireless transmission technique Standard Musical Expression, a representation of simple music in ASCII used in QBasic and other software StepManiaX, a rhythm game by Step Revolution Sulfamethoxazole, an antibiotic SuperMotocross World Championship, the premier combined discipline of American off-road motorcycle racing.

As a code: Santa Maria Public Airport, in California, US, IATA code C.A.I. First, regional Italian airline, ICAO airline code SMTC Corporation, Canada, TSX/Toronto ticker code Sanmenxia city in Henan, China, governmental code SMX Sendmail X, now MeTA1, mail server coded smX Special Mobile Machine—Exempt, prefix SMX, on vehicle registration plates of Colorado