Uylenburgh is a surname. Notable people with the surname include:
Gerrit van Uylenburgh (1625–1679), or Gerrit Uylenburgh, Dutch art-dealer Hendrick van Uylenburg (1587–1661), Dutch Golden Age art dealer Rombertus van Uylenburgh (1554–1624), best known as father of Saskia van Uylenburgh, wife of Rembrandt Saskia van Uylenburg (1612–1642), wife of the Dutch painter Rembrandt van Rijn