Pirandello is a rare Italian surname from Sicily. Notable people with the surname include:
Fausto Pirandello (1899–1975), Italian painter, son of Luigi Luigi Pirandello (1867–1936), Italian dramatist, novelist, poet, and short story writer Stefano Pirandello (1895–1972), Italian dramatist and writer, son of Luigi
See also 12369 Pirandello, a main-belt asteroid