Applewhite is a surname. Notable people with the surname include:
Antwan Applewhite (born 1985), American football player Ashton Applewhite (born 1952), American writer and activist Charlie Applewhite (1932–2001), American singer James Applewhite (born 1935), American poet Major Applewhite (born 1978), American football coach Marshall Applewhite (1931–1997), American cult leader
Fictional characters: Betty Applewhite, Desperate Housewives character
See also Surviving the Applewhites, novel Isaac Applewhite House, historic site Ward-Applewhite-Thompson House, historic site W. H. Applewhite House, historic site