4-Benzylpiperidine is a drug and research chemical used in scientific studies. It has been encountered as a designer drug.
Pharmacology 4-Benzylpiperidine acts as a monoamine releasing agent with 20- to 48-fold selectivity for releasing dopamine versus serotonin. It is most efficacious as a releaser of norepinephrine, with an EC50 of 109nM (DA), 41.4nM (NE), and 5,246nM (5-HT).
It also functions as a weak monoamine oxidase inhibitor (MAOI) ( = 130μM for and 750μM for ).
The drug has a fast onset of action and a short duration.
Synthesis 4-Cyanopyridine can be reacted with toluene to give 4-benzylpyridine. Catalytic hydrogenation of the pyridine ring then completes the synthesis.
Applications RMI-10608 is a derivative of 4-benzylpiperidine and analog of haloperidol that was discovered to have potential use in treating psychosis and preventing brain damage by virtue of its NMDA antagonist pharmacology.Rafael Foguet, et al. (1995 to Ferrer Internacional SA).Sui Xiong Cai, et al. WO1996002250 (Cocensys Inc, Acea Pharmaceuticals Inc).
See also 2-Benzylpiperidine Benzylpiperazine Tetrahydroisoquinoline
References