RU-24969, also known as 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)indole (5-MeO-THPI), is a serotonin receptor modulator of the tetrahydropyridinylindole group related to 5-MeO-DMT which is used in scientific research.
Pharmacology Pharmacodynamics RU-24969 is a selective agonist of the serotonin 5-HT1A and 5-HT1B receptors, with 5-fold preference for the latter receptor over the former. In studies, its affinities (Ki) were 2nM for the serotonin 5-HT1 receptor, 5nM for the serotonin 5-HT1A receptor, 4nM for the serotonin 5-HT1B receptor, 780 to 1,000nM for the serotonin 5-HT2 receptor, and 400nM for the serotonin 5-HT2C receptor. It also has affinity for the serotonin 5-HT5A, 5-HT5B, and 5-HT7 receptors.
The drug produces MDMA-like locomotor hyperactivity in animals and this is thought to be mediated by activation of both serotonin 5-HT1A and 5-HT1B receptors. As with other serotonin 5-HT1B receptor agonists such as CP-94253, RU-24969 has also been found to increase the reinforcing properties of cocaine in animals, suggesting a role for serotonin 5-HT1B receptors in cocaine addiction as well. The drug produces antiaggressive effects in rodents. It did not increase oxytocin levels in rodents.
Chemistry Many analogues of RU-24969 have been studied and described.
History RU-24969 was first described in the scientific literature by 1980.
See also Serotonin 5-HT1B receptor agonist Tetrahydropyridinylindole Substituted tryptamine § Related compounds EMD-386088 RS134-49 RU-28253 RU-28306 SN-22
References
External links RU-24969 - Isomer Design