William Durham may refer to:
William H. Durham (born 1949), human ecologist at Stanford University William Howard Durham (1873–1912), Pentecostal pioneer and theologian William J. Durham (1896–1970), African-American attorney and civil rights leader William Durham (tennis), Australian tennis player William Durham (chemist) FRSE (1834–1893)
See also William of Durham (died 1249), said to have founded University College, Oxford, England