Prentiss House may refer to:
Prentiss-Payson House, Arlington, Massachusetts, listed on the National Register of Historic Places (NRHP) William Prentiss House, Arlington, Massachusetts, NRHP-listed Prentis House, Hadley, Massachusetts Addison Prentiss House, Worcester, Massachusetts, NRHP-listed Warren-Prentis Historic District, Detroit, Michigan, NRHP-listed Frederick Prentiss House, Columbus, OH, listed on the NRHP in Ohio Prentiss-Tulford House, Columbus, OH, listed on the NRHP in Ohio
See also Mary Prentiss Inn, Cambridge, Massachusetts, USA Prentiss (disambiguation)