Transient neonatal diabetes mellitus (TNDM) is a form of neonatal diabetes presenting at birth that is not permanent. This disease is considered to be a type of maturity onset diabetes of the young (MODY).
Types
Type OMIM Gene Locus Description TNDM1 ZFP57, PLAGL1 6p22.1, 6q24.2 TNDM2 ABCC8 11p15.1 Due to the mutations of the other subunit of the KATP channel, SUR1, which is encoded by the ABCC8 gene. TNDM3 KCNJ11 11p15.1 Cause This condition has to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side).
The form on chromosome 6 can involve imprinting. See also Permanent neonatal diabetes mellitus
References
Further reading GeneReview/NIH/UW entry on 6q24-Related Transient Neonatal Diabetes Mellitus External links