Griffin House may refer to:
People Griffin House (musician), American musician
Places in Canada Griffin House (Ancaster), a 19th-century house and museum, site along the Underground Railroad
in the United States (by state then town or city) Alfred Griffin House, Yuma, Arizona, listed on the National Register of Historic Places (NRHP) in Yuma County Willard Griffin House and Carriage House, Los Altos, California, listed on the NRHP in Santa Clara County Smith Griffin House, Hampton, Georgia, listed on the NRHP in Henry County Griffin House (Portland, Maine), NRHP-listed Griffin House (Moss Point, Mississippi), NRHP-listed Griffin-Spragins House, Greenville, Mississippi, NRHP-listed Smart-Griffin House, Natchez, Mississippi, listed on the NRHP in Adams County W. W. Griffin Farm, Williamston, North Carolina, listed on the NRHP in Martin County A.B. Griffin-O.H. Griffin House, Ravenna, Ohio, listed on the NRHP in Portage County Alexander B. Griffin House, Ravenna, Ohio, listed on the NRHP in Portage County Griffin House (Chickasha, Oklahoma), listed on the NRHP in Grady County John N. Griffin House, Astoria, Oregon, NRHP-listed Griffin-Christopher House, Pickens, South Carolina, NRHP-listed Mary S. and Gordon Griffin House, McAllen, Texas, listed on the NRHP in Hidalgo County