Charles Upton may refer to:
Charles W. Upton (born c. 1943), American economist Charles H. Upton (1812–1877), politician and statesman from Massachusetts and Virginia Charles Upton (poet) (born 1948), American poet, Sufi and metaphysician Charles L. Upton (1870–1936), American physician and college football coach Charles Upton Lowe (1921–2012), for whom Oculocerebrorenal syndrome or Lowe syndrome was named Charles Upton, High Sheriff of Derbyshire in 1809