George Middleton may refer to:
George Middleton (activist) (1735–1815), African-American Revolutionary War veteran, activist, and Freemason George Augustus Middleton (1791–1848), English-Australian pastor and farmer George Middleton (American politician) (1800–1888), New Jersey congressman George H. Middleton (died 1892), Scottish engineer George "Bay" Middleton (1846–1892), British equestrian Sir George Middleton (British politician) (1876–1938), Labour member of parliament for Carlisle 1922–1924, 1929–1931 George E. Middleton, American film director and producer George Middleton (playwright) (1880–1967), American playwright, director, and producer George Middleton (trade unionist) (1898–1971), general secretary of the Scottish Trades Union Congress Sir George Middleton (diplomat) (1910–1998), British diplomat