Dinara Safina was the defending champion but lost in the quarterfinals to Amélie Mauresmo.
Mauresmo went on to win the title, defeating Mary Pierce in the final 6–1, 7–6(7–2).
Seeds A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated. The top four seeds received a bye to the second round.
Amélie Mauresmo (champion) Mary Pierce (final) Nadia Petrova (quarterfinals) Patty Schnyder (semifinals) Elena Dementieva (quarterfinals) Flavia Pennetta (first round) Dinara Safina (quarterfinals) Anna-Lena Grönefeld (first round)
Draw
Final
Section 1
Section 2
External links 2006 Open Gaz de France draw