Eskin is a surname. Notable people with the surname include:
Alex Eskin (born 1965), American mathematician Arnold Eskin (1940–2019), chronobiologist Avigdor Eskin (born 1960), Russian-Israeli journalist Eleazar Eskin, American computer scientist and geneticist Gregory Eskin (born 1936), Russian-Israeli-American mathematician Howard Eskin (born 1951), American sports anchor Jules Eskin (1931–2016), American cellist Virginia Eskin (born 1940), American pianist
See also Eskin-e Olya, Iran Eskin-e Sofla, Iran Eskin, Kızıltepe, Turkey Eskini, California