Frank O'Donnell may refer to:
Frank O'Donnell (footballer) (1911–1952), Scottish professional footballer Frank O'Donnell (actor) (1907–1956), Australian actor Frank A. O'Donnel (1852–1906), New York politician Frank Hugh O'Donnell (1846–1916), Irish nationalist writer and politician Frank J. Hugh O'Donnell (1894–1976), Irish critic, playwright and politician Francis Martin O'Donnell (born 1954), Irish and international diplomat, Ambassador of the Sovereign Order of Malta to Slovakia and retired former UN Resident Coordinator