Pinogana District () is a district (distrito) of Darién Province in Panama. The population according to the 2000 census was 12,823; the latest estimate (for 2019) is 26,160.Instituto Nacional de Estadística y Censo, Panama. The district covers a total area of . The capital lies at the town of El Real de Santa María.

Administrative divisions Pinogana District is divided administratively into the following corregimientos:

El Real de Santa María Boca de Cupe Paya Pinogana Púcuro Yape Yaviza Metetí

Note: - The indigenous comarca of Wargandi lies within Pinogana District; although it constitutes administratively and independently as a separate corregimiento).

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