Big Joe may refer to:
People Joe Curtis (1882–1972), American college football player and coach Big Joe Duskin (1921–2007), American blues and boogie-woogie pianist Big Joe Krash, pseudonym of American rapper KRS-One Joseph Lonardo (1884–1927), American Mafia crime boss Big Joe Mufferaw, French Canadian folk hero Big Joe Nasty, ring name of Joe D'Acquisto, American professional wrestler Joe Roberts (actor) (1871–1923), American comic actor Joseph Todaro Jr. (born 1945 or 1946), American businessman and alleged Mafia crime boss Big Joe Turner (1911–1985), American blues shouter Joe Vagana (born 1975), New Zealand former rugby league footballer Joe van Niekerk (born 1980), South African former rugby union player Big Joe Williams (1903–1982), American Delta blues musician and songwriter Big Joe (reggae), Jamaican deejay born Joseph Spalding in 1955
Space exploration Big Joe (Project Mercury), a subprogram of Project Mercury Big Joe 1, a Project Mercury mission Big Joe, a rock on Mars - see List of rocks on Mars
Other uses Big Joe (bell), a bell in Saint Francis De Sales Catholic Church, Cincinnati, Ohio Big Joe (mascot), the mascot of the Ottawa Redblacks of the Canadian Football League Big Joe (dinosaur), the most complete and best-preserved Allosaurus fossil known to date Big Joe, Robert Een's band Big Joe, a novel by Samuel R. Delany
See also Joseph Massino (born 1943), American former Mafia crime boss nicknamed "Big Joey"