Prospect Avenue may refer to:

Prospect Avenue (Kansas City, Missouri), a street that runs close to U.S. Route 71 Hollywood Boulevard, Los Angeles (named Prospect Avenue between 1887 and 1910) Prospect Avenue (Brooklyn), New York City

New York City Subway stations Prospect Avenue (IRT White Plains Road Line), in the Bronx; serving the trains Prospect Avenue (BMT Fourth Avenue Line), in Brooklyn; serving the trains