VSB may refer to:
Organizations Vancouver School Board, common name for School District 39 Vancouver, British Columbia United Swiss Railways (), a former railway company in Switzerland Villanova School of Business at Villanova University, Philadelphia, Pennsylvania Virginia State Bar, an administrative agency of the Supreme Court of Virginia Völkisch-Social Bloc, a right-wing electoral alliance in post-World War I Germany VSB-TV, a defunct NBC affiliate in Bermuda Technical University of Ostrava (), in the city of Ostrava, Czech Republic
Other uses Finno-Soviet Treaty of 1948 (), the basis for Finno–Soviet relations from 1948 to 1992 Vestigial sideband, in radio communications, a sideband that has been only partly cut off or suppressed Very small business, companies that are at the lower end, in terms of size, to companies that are considered small and medium enterprise VSB, (voltage standby), a power supply line on an ATX motherboard form factor that stays active when the power supply is not active Space Quest: Vohaul Strikes Back, a fan-made sequel to the Space Quest video game series