Keefer is the surname of:
Charles Keefer (1852–1932), Canadian engineer Chester Keefer (1897–1972), American physician, medical researcher, and medical school dean Don Keefer (1916–2014), American actor Francis Henry Keefer (1860–1928), Canadian lawyer and politician George Keefer (1921–1985), Canadian World War II flying ace and wing commander Janice Kulyk Keefer (born 1952), Canadian novelist and poet Johnny Keefer (born 2001), American professional golfer Mel Keefer (1926–2022), American artist Philip B. Keefer (1875–1949), United States Navy sailor and a recipient of the Medal of Honor Thomas Keefer (1821–1915), Canadian civil engineer
See also Keefers, British Columbia, Canada, a railway point and ghost town Kefer, a surname Kiefer, a given name and surname Kiefer, Oklahoma, United States, a town
See also Kefer, another surname Kiefer, a given name and surname Kefir, a fermented milk dring