Saint-Côme is the French spelling for Saint Cosmas and may also refer to:
Places It may refer to several communities around the world: Canada Saint-Côme, Quebec, a parish municipality in the province of Quebec Saint-Côme–Linière, Quebec, a municipality in the province of Quebec
France Saint-Côme, a commune in the Gironde department in Aquitaine Saint-Côme-d'Olt, a commune in the Aveyron department Saint-Côme-de-Fresné, a commune in the department of Calvados in the Basse-Normandie region Saint-Côme-du-Mont, a commune in the Manche department in Normandy Saint-Côme-et-Maruéjols, a commune in the Gard department
Other Saint Come, a wine label