Sixto is a Spanish name. It may refer to:
People with the given name Sixto Brillantes (1939–2020), Filipino election lawyer Sixto Casanovas (1802–1852), Argentine cavalry officer, politician Sixto Durán Ballén (1921–2016), Ecuadorian architect, president Sixto Escobar (1913–1979), Puerto Rican professional boxer Sixto González (born 1965), Puerto Rican astronomer, director of the Arecibo Observatory Sixto Kaipat Igisomar, politician from the Northern Mariana Islands. Sixto Lezcano (born 1953), Puerto Rican born baseball outfielder Sixto López (1863–1947), Philippine activist, diplomat Sixto Palavecino (1915-2009), Argentine poet, folk musician Sixto Peralta (born 1979), Argentine football midfielder Sixto Rodriguez (1942-2023), American singer-songwriter Sixto Sánchez (born 1998), Dominican born baseball player Sixto Soria (born 1954), Cuban boxer Sixto Valencia Burgos (1934–2015), Mexican cartoon artist Sixto Vizuete (born 1961), Ecuadorian football coach
People with the surname Adolph Sixto (1859-1930), author, lecturer, lobbyist and naturalist from Saint Thomas, U.S. Virgin Islands Maurice Sixto (1919–1984), Haitian author