Depot Historic District or Depot Square Historic District may refer to:
Depot-Compress Historic District, Holly Springs, Mississippi, listed on the National Register of Historic Places (NRHP) in Marshall County, Mississippi Meridian Depot Historic District, listed on the NRHP in Mississippi Depot Historic District (Marion, North Carolina), listed on the NRHP in North Carolina Depot Historic District (Raleigh, North Carolina), listed on the NRHP in North Carolina Depot Square Historic District (Wichita Falls, Texas), listed on the NRHP in Wichita County, Texas Depot Square Historic District (Randolph, Vermont), listed on the NRHP in Orange County, Vermont