Ephraim Williams (1715–1755) was an American soldier; benefactor of Williams College in Massachusetts.
Ephraim Williams may also refer to:
Ephraim Williams Sr. (1691–1754), colonial Massachusetts surveyor and land owner, instrumental in dispossession of the Mohicans Ephraim S. Williams (1802–1890), mayor of Flint, Michigan Ephraim Williams (footballer) (1877–1954), Druids F.C. and Wales international footballer Ephraim Williams (circus owner) (1860–1921), African American variety show proprietor Ephraim Williams (mariner), 19th-century American sealer from Stonington, Connecticut, see Express Island Ephraim Williams, a ship sunk off North Carolina in 1884; see wreck of the Ephraim Williams