Appalachia is a socioeconomic region associated with the Appalachian Mountains in the eastern United States.

Appalachia may also refer to:

Appalachian (disambiguation) Appalachia (Mesozoic), a Mesozoic-era island Appalachia, Virginia, a town in the U.S. state of Virginia Appalachia, a rhapsody by Frederick Delius Appalachia (journal), a mountaineering and conservation journal published by the Appalachian Mountain Club since 1894 Appalachia (grasshopper), a genus of grasshopper from eastern North America

See also Apalachin (disambiguation) Apalachin, New York