Obafemi is both a surname and a given name. Notable people with the name include:
Abiodun Obafemi (born 1973), Nigerian footballer Afolabi Obafemi (born 1994), English footballer Michael Obafemi (born 2000), Irish footballer Obafemi Anibaba, Nigerian civil servant and businessman Obafemi Awolowo (1909–1987), Nigerian politician and leader Obafemi Ayanbadejo (born 1975), American football fullback Obafemi Lasode (born 1955), Nigerian actor Obafemi Martins (born 1984), Nigerian football player Obafemi Obadare, Nigerian journalist
See also Obafemi Awolowo University, a government-owned and operated Nigerian university Oba Femi (born 1998), Nigerian professional wrestler