William Nisbet may refer to:
William Nisbet MP (1666–1724), one of the Scottish representatives to the first Parliament of Great Britain William Nisbet (physician) (1759–1822), Scottish physician William Hamilton Nisbet (1747–1822), British politician William Nisbet (mason), Grand Master of the Grand Lodge of Scotland, 1746–1747 William Nisbet of Dean, Scottish merchant who twice served as Provost of Edinburgh
See also William Nesbit (disambiguation)