Tsintsadze () is a Georgian surname. Notable people with the surname include:
Besa Tsintsadze (born 1969), Georgian figure skater Dito Tsintsadze (born 1957), Georgian film director and screenwriter Giorgi Tsintsadze (born 1986), Georgian basketball player Irakli Tsintsadze (born 1964), Georgian composer Ivanna Klympush-Tsintsadze (born 1972), Ukrainian politician and journalist Kalistrate Tsintsadze (Callistratus of Georgia; 1866–1952), Catholicos-Patriarch of All Georgia Kote Tsintsadze (1887–1930), Georgian communist politician Mate Tsintsadze (born 1995), Georgian professional footballer Sulkhan Tsintsadze (1925–1991), Georgian composer