Saperstein (compound of Hebrew sapir "sapphire" + German Stein "stone") is a surname. Notable people with the surname include: Abe Saperstein (1902–1966), founder and coach of the Savoy Big Five, which later became the Harlem Globetrotters Abram Saperstein, changed his name to Albert Sabin (1906–1993), Polish-American medical researcher who developed an oral polio vaccine; President of the Weizmann Institute of Science David Saperstein (disambiguation) Esther Saperstein (1901–1988), American politician Harlan Saperstein, television narrator Larry Saperstein (born 1998), American actor

Fictional entities Fictional entities with the surname include: Dr. Lu Saperstein, a fictional obstetrician in Parks and Recreation, played by Henry Winkler Jean-Ralphio Saperstein, a fictional character in Parks and Recreation, played by Ben Schwartz Mona Lisa Saperstein, a fictional character in Parks and Recreation, played by Jenny Slate