Southwest Historic District may refer to:
Southwest Holly Springs Historic District, Holly Springs, MS, listed on the NRHP in Mississippi Southwest Historic District (Waltons Store, North Carolina), listed on the NRHP in North Carolina Hickory Southwest Downtown Historic District, Hickory, NC, listed on the NRHP in North Carolina Southwest Historic District (Roanoke, Virginia), listed on the NRHP in Virginia Southwest Mountains Rural Historic District, Keswick, VA, listed on the NRHP in Virginia Southwest Virginia Museum Historical State Park, Big Stone Gap, VA, listed on the NRHP in Virginia Southwest Historic District (Ripon, Wisconsin), listed on the NRHP in Wisconsin Southwest Side Historic District, Stoughton, WI, listed on the NRHP in Wisconsin