U.S. Route 301 (US 301) is a U.S. Highway in the U.S. state of Georgia. It travels south-to-north from the St. Marys River south-southeast of Folkston to the Savannah River north-northeast of Sylvania, via Folkston, Jesup, Ludowici, Glennville, Claxton, Statesboro, and Sylvania.

The highway is concurrent with various state highways in Georgia. It uses SR 4/SR 15 from the Florida state line to Homeland, SR 23 from Folkston to Glennville, SR 38 from Jesup to Ludowici, SR 57 from Ludowici to Glennville, SR 73 from Glennville to the South Carolina state line, and SR 73 Loop along the western edge of Sylvania. US 301 is concurrent with US 25 from Jesup to Statesboro.

Route description

Florida State Line to Jesup The route starts at the Florida state line on a bridge over the St. Marys River in eastern Charlton County, and initially travels north as a four-lane highway through Folkston, concurrent with US 1, US 23, and SR 4/SR 15. In Folkston, the highway intersects Main Street. One block later, the road intersects Love Street, and later is joined by SR 23/SR 121 where another concurrency begins. A connecting route begins along the east side to travel towards SR 40. In Homeland, US 1/US 23/SR 4/SR 15/SR 121 turns to the northwest at an interchange where it crosses into Ware County, while US 301/SR 23 heads north into northeastern Charlton County.

Throughout most of southern Georgia, US 301/SR 23 travels through rural Charlton county then crosses the Charlton–Brantley County line. US 301/SR 23 curves to the northeast after Taylor Bay Boulevard. In Hickox, the road curves back towards the north as it briefly widens to accommodate left turn lanes for Brantley CR 79. Before crossing this road, the right-of-way for a former segment begins on the southeast corner of this intersection and follows the existing road along the east side until it reaches the bridge over Buffalo Creek. The former section resumes after the bridge, and the road has right-turn lanes as it approaches a road named for the creek. North of Britt Still Road an unfinished frontage road can be found along the west side, approaching a trailer park and local church. Both sections end after this mobile home community.

A clear sign that the road is approaching Nahunta is a second southbound lane just south of Brantley CR 70 (Robin Lane). Within the city limits the road is named South Main Street. US 301/SR 23 heads north across US 82/SR 520. After this intersection, South Main Street becomes North Main Street. The road passes by the Nahunta City Hall, and Satilla Avenue. Continuing north, crosses a railroad track, and passes by the Hotel Knox, at Broome Street and Florida Avenue, a five-way intersection. The road leaves the city limits. It then gains a second northbound lane which ends just before the road enters Raybon. North of CR 102, The road crosses over a culvert leading from Strickland Lake before intersecting with Brantley CR 103. North of CR 103, a former segment of the road can be found at a local automotive repair shop, and is found again on the east side of the road south of the intersection with Brantley CR 299 (Laural Road). The right of way for this former segment remains on the right side, and is even used as a boat-launching area as US 301/SR 23 crosses a bridge over the Satilla River. After the bridge, the former section resumes on the same side. Traveling through Trudie. Shortly after this it crosses a bridge over the Little Satilla River, followed by another bridge over an overflow creek to the river. A second bridge over another overflow creek to the river can be found north of the first overflow bridge. The right-of-way for this former segment ends just after that second overflow bridge. After this bridge, the route enters Hortense. Intersecting with SR 32. Just north of the intersection, US 301/SR 23 crosses a power line right-of-way, and passes the intersection of a long dirt road named Old Hortense Road. Just after the intersection with Perry Rozier Road on the west side the routes cross the Brantley–Wayne County line and has an intersection with Loper–Bryan Road on the east side. North of the county line, the road is named Pine Street.

After the intersection with Ed Harrell Road and later some unnamed dirt roads, the route crosses over a bridge over Barbers Creek. An extra southbound lane forms and then comes to an end just before an intersection with an unnamed dirt road traveling northwest and southeast. After passing two unnamed dirt roads, US 301/SR 23 enters McKinnon and immediately intersects a dirt road, along with three other dirt roads. The routes also pass a cell phone tower just south of the intersection of Fire Tower Road. Shortly after this, US 301/SR 23 becomes Old Hortense Road. In Broadhurst the route encounters Broadhurst Road West which leads to Screven, and then Broadhurst Road East which leads to Gardi and Manningtown. After this, a second northbound lane appears momentarily and ends in another wooded area. After the bridge over Little Penholoway Creek, the road intersects Long Fork Road, which branches off to the northeast. Just before entering Jesup the routes pass by the Jesup-Wayne County Airport, and then the Pine Forest Country Club. In the city itself, US 301/SR 23 crosses US 341/SR 27, where northbound US 25 turns from US 341 onto US 301/SR 23, and then travels over a bridge. The three highways travel to the north-northeast in the northeast part of the city. They curve to the north, approaching a bridge, then merges with US 84/SR 38 at a partial wye interchange. Immediately afterward, the five highways travel to the northeast and leave the city limits. The concurrency travels through rural parts of the county, passing the Jesup Drive-In, and then a Rayonier Performance Fibres plant near Doctortown, curving to the north, then crossing over the Altamaha River into Long County on the Dr. J. Alvin Leaphart Sr. Memorial Bridge.

Concurrency with US 25

The combined routes (US 25/US 84/US 301/SR 23/SR 38) continue to the northeast and travel through rural areas of the county, crossing over tributaries of the Altamaha River such as Forrest Pond, Back Swamp (in two places), Corker Branch, Fountain Branch, Brickyard Branch, and Jones Creek on its way to Ludowici. In town, the concurrency intersects SR 57 south, which travels to the southeast. At this intersection, US 25/US 301/SR 23, as well as SR 57 north, travel to the northwest in a new concurrency, while US 84/SR 38 continue to the northeast. This segment of the highway is named North McDonald Street until roughly around Macon Darien Road where it becomes Cecil Nobles Highway. After a slight jog more towards the northwest, the roadway crosses through Wefanie. Just before leaving the county, they intersect the southwest terminus of former SR 261, today known as Marcus Nobles Road. Right after that, they curve to the north-northwest and cross over Beards Creek into Tattnall County.

US 25/US 301/SR 23/SR 57 travel to the east of Kicklighters Pond. In Glennville, the concurrency makes its strongest effort to move from northwest to northeast at the intersection of SR 196. However, only in "downtown" Glennville does SR 23/SR 57 split off to the northwest at the intersection of SR 144. SR 73 begins there, taking US 25/US 301 north from Glenville. Within the city, the road travels through a diagonal intersection with Hencart Road, a local street that leads northeast and southwest to the western end of the SR 23/SR 57/SR 144 concurrency. Just after leaving the city limits, the highways pass the Georgia Veterans Memorial Cemetery – Glennville, Stricklands Pond, and Strickland Pond Dam. After passing a bridge over Chapel Creek, the concurrency travels along the west side of Smith State Prison, where it begins to curve to the north. They curve to the north-northwest at Tattnall CR 403 and CR 374, then back to the north-northeast and cross over Beards Creek just before intersecting the southern terminus of what used to be SR 250. After passing to the east of Durrence Pond, just west of Midway, US 25/US 301/SR 73 crosses into Evans County.

The concurrency passes to the east of Union Cemetery and then to the west of Evans Heights Golf Club. Approximately later, it crosses over Bull Creek. After a westward jog past Richards Pond, the highways curve to a due north routing and where it travels between the Claxton Elementary School and a local storage facility before entering Claxton. In downtown, the roads pass by The Georgia Fruitcake Company then cross a railroad line right before the intersection with US 280/SR 30/SR 129 (Main Street). Just after the intersection of Martin Luther King Jr. Drive/East Long Street, the highways curve to the northeast. Just northeast of the city limits, US 25/US 301/SR 73 passes southeast of the Claxton Sewage Treatment Pond and the accompanying dam. About later, they cross over the Canoochee River on the Claxton Bridge. They provide access to the Claxton–Evans County Airport and then curve to the north-northwest. After curving back to the north-northeast, the highways curve to a due north routing and intersect the northern terminus of SR 169. About later, they cross into Bulloch County.

Statesboro to the South Carolina state line