The Jefferson Hotel in Shreveport, Louisiana is a four-story brick railway hotel that was built in 1922. It was listed on the National Register of Historic Places in 1989. It also became a contributing property of Shreveport Commercial Historic District when its boundaries were increased on .

It was designed by architect H.E. Schwartz and served the travelers of Union Depot Station, which was located across the street, until its demolition in 1972. Alterations, particularly to the exterior, have been minimal since its construction. (with three photos and a map)

See also National Register of Historic Places listings in Caddo Parish, Louisiana

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