HDF may refer to: Places Hadfield railway station (station code), Derbyshire, England Hauts-de-France, a French region Heringsdorf Airport (IATA code), Garz, Germany Hôtel-Dieu de France, Lebanon
Organisations Hereditary Disease Foundation, an American organization Human Development Foundation, Thailand Human Diversity Foundation, a far-right eugenicist organization Hungarian Defence Force
Science and technology Hierarchical Data Format, a file format High-density fiberboard, a wood product Hortonworks DataFlow, real-time streaming analytics software Hubble Deep Field, an astronomical image Hydrodefluorination, a chemical reaction