Heiser is a surname. Notable people with the surname include:
Charles Bixler Heiser (1920–2010), American botanist Francis Heiser (died 1952), British priest Gernot Heiser (born 1957), Australian professor Joseph M. Heiser Jr., American general Michael S. Heiser, American scholar and author Rolland V. Heiser, American general Roy Heiser (born 1942), American baseball player Willem Heiser (born 1949), Dutch social scientist