Wolffe is a surname of English and Jewish (Ashkenazic) origin. Variant of Wolf, Wolff or Wolfe . Notable people with the surname include:
Alan Wolffe (1959–2001), British cell biologist Jabez Wolffe (1876–1943), British swimmer who attempted to swim the English Channel many times James Wolffe (born 1962), Scottish lawyer Richard Wolffe (born 1968), British-American journalist, MSNBC commentator and author Andrew Wolffe (born1964), Scottish Designer
See also Eva de Wolffe, a character in the UK TV series Footballers' Wives Commander Wolffe, the clone CC-3636 who was the leader of the Wolfpack Wolf Wolfe (disambiguation) Wolff Woolf